Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Comparative effectiveness review of nonirradiated allografts for primary anterior cruciate ligament reconstruction. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem:
The anterior cruciate ligament (ACL) is 1 of 4 major ligaments in the knee joint that maintain stability of the joint. Most ACL injuries are complete or near-complete tears resulting in substantial joint instability. Technology Description:
ACL reconstruction is a surgical procedure in which a torn ACL is replaced with a tendon graft retrieved from the patient's body (autograft) or a human donor, usually a cadaver (allograft). This report focuses on the comparison of nonirradiated allografts with autografts for primary reconstruction of ACL injuries.
Controversy:
Use of an autograft tendon is associated with donor site morbidity, longer surgical times, and the risk of
unsuitability of harvested graft material (e.g., insufficient graft size, poor quality). While allografts overcome these limitations, they carry risks of infectious agent transmission, immune response, and delayed incorporation.
Key Questions:
Are nonirradiated allografts effective in repairing knee function following anterior cruciate ligament (ACL) reconstruction? How do nonirradiated tendon allografts compare with autografts with regard to knee function following ACL reconstruction? Are nonirradiated tendon allografts safe? Have definitive patient selection criteria been identified for the use of nonirradiated allografts? Indexing Status Subject indexing assigned by CRD MeSH Allografts; Anterior Cruciate Ligament Reconstruction; Humans; Transplantation, Homologous Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32018000095 Date abstract record published 15/02/2018 |