Is impedance threshold device effective in resuscitation of out-of-hospital cardiac arrest patients?
Searches
(impedance threshold device. mp.) AND [(cardiac arrest.mp. or exp Heart Arrest/) OR (exp Resuscitation/ or resuscitation.mp. or exp Cardiopulmonary Resuscitation/)], limited to humans, filter by randomized controlled trial
Types of study to be included
randomized controlled trials
Condition or domain being studied
cardiopulmonary resuscitation
Participants/ population
patients of out-of-hospital cardiac arrest
Intervention(s), exposure(s)
impedance threshold device
Comparator(s)/ control
sham device
Outcome(s)
Primary outcomes
return of spontaneous circulation
Secondary outcomes
short-term survival, survival to hospital discharge, satisfactory outcome
Risk of bias (quality) assessment
The Cochrane risk of bias tool was adopted to assess the risk of bias for each RCT. Each RCT was scored as “high risk,” “low risk,” or “unclear” with respect to random sequence generation, allocation concealment, blinding process, incomplete outcome data, and selective reporting.
Strategy for data synthesis
Data synthesis and analysis were performed using R 2.11.1 software (R Foundation for Statistical Computing; Vienna, Austria) in the metafor package. A two-sided p value = 0.05 was considered statistically significant. Dichotomous outcomes were collected to determine risk ratios (RRs) with 95% confidence intervals (CIs) of the individual studies. Heterogeneity was tested according to the I-squared statistic, in which I-squared=50% indicated a substantial level of heterogeneity, and the statistical test of heterogeneity, in which p=0.05 indicated heterogeneity. The random-effects summary estimates (according to the DerSimonian–Laird method) were reported if significant heterogeneity was evident according to either test; otherwise, fixed-effect summary estimates (according to the Mantel–Haenszel method) were reported.
Analysis of subgroups or subsets
We performed a priori subgroup analysis by CPR method.
Contact details for further information
Chih-Hung Wang
Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Formal screening of search results against eligibility criteria
Data extraction
Risk of bias (quality) assessment
Data analysis
Prospective meta-analysis
PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites.
