The diagnostic accuracy of panoramic radiography to detect osteoporosis in postmenopausal women
Searches
We will search MEDLINE, SCIELO, BIREME and Cochrane Library for papers published between January 1980 to September 2012. The reference lists of related systematic reviews will be scanned for potentially eligible studies. Details of the search strategy will be available from the authors on request. No language restriction will be applied.
Handsearching of reference lists
The references of all included studies will be scanned to check for further relevant articles based on their titles and abstract reading.
Types of study to be included
Accuracy and agreement diagnostic studies
Condition or domain being studied
Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Participants/ population
Postmenopausal women
Intervention(s), exposure(s)
Panoramic radiography in postmenopausal women
Comparator(s)/ control
Bone density measure with diagnostic of osteoporosis
Context
Osteoporosis is a pathological condition characterized by loss of bone mineral density and microarchitectural deterioration of bone tissue that leads to bone fragility and risk of fractures, . This bone loss begins around age 35 and continues at different rates throughout life, affecting many of the female gender, particularly after menopause, when bone loss accelerates. Previous reports indicate the diagnostic potential of panoramic radiography for the diagnosis of osteoporosis, however primary reports and previous reviews have shown conflicting results.
Outcome(s)
Primary outcomes
true positive and negative cases of osteoporosis
Secondary outcomes
none
Data extraction, (selection and coding)
Two reviewers will independently select the studies eligible for inclusion in the review, using titles and abstracts, and full text as needed. Disagreements will be resolved by consensus, and if consensus can not be reached a third reviewer will be consulted if necessary.
Data will be extracted by one reviewer and checked by a second on a standardised form, with emphasis in Indice Mandibular Cortical o MCI, Ancho Cortical o MC , Indice Panorámico Mandibular o PMI , Indice Mental o MI.
Risk of bias (quality) assessment
Risk of bias of included studies will be assessed by two reviewers independently using the QUADAS-2 Tool.
Strategy for data synthesis
After obtaining the individual results of each study, we will calculate the sensitivity, specificity, and likelihood of selected articles. We will calculate the diagnostic odds ratio (DOR) to assess the diagnostic test accuracy (the higher the DOR, more accuracy) with the corresponding confidence interval (95%).
Analysis of subgroups or subsets
None planned
Dissemination plans
This systematic review will be published in a peer reviewed journal and presented at National/International conferences.
Contact details for further information
Sergio Uribe
Luis Rudloff 1640
Valdivia
CHILE
sergiouribe@uach.cl
Organisational affiliation of the review
School of Dentistry, Faculty of Medicine, Universidad Austral de Chile
www.uach.cl
Review team
Professor Sergio Uribe, Universidad Austral de Chile Dr Paula Alvarez, Universidad Austral de Chile
Formal screening of search results against eligibility criteria
Data extraction
Risk of bias (quality) assessment
Data analysis
Prospective meta-analysis
PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites.
