Use of Beta-2-agonists in acute lung injury/acute respiratory distress syndrome
Searches
A comprehensive search of several databases from their origin to March 2012 (any language, any population) was conducted. The databases included Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials (CENTRAL), Ovid Cochrane Database of Systematic Reviews, Web of Science, and Scopus. The search strategy was designed and conducted by an experienced librarian with input from the study’s principle investigator. Controlled vocabulary supplemented with keywords was used to search for studies using beta-2-agonist for acute lung injury/acute respiratory distress syndrome.
1. Acute lung injury- a pressure of arterial oxygen to fractional inspired oxygen concentration (PaO2/FIO2) ratio of 300 mm Hg or less, bilateral pulmonary infiltrates consistent with oedema, and the absence of clinically evident left atrial hypertension.
2. Acute respiratory distress syndrome patients - a pressure of arterial oxygen to fractional inspired oxygen concentration (PaO2/FIO2) ratio of 200 mm Hg or less, bilateral pulmonary infiltrates consistent with oedema, and the absence of clinically evident left atrial hypertension.
Intervention(s), exposure(s)
Use of Beta-2-agonists.
Comparator(s)/ control
Non use of Beta-2-agonists (placebo).
Outcome(s)
Primary outcomes
Mortality - hospital mortality and 28-days mortality.
Secondary outcomes
Ventilator free days.
Risk of bias (quality) assessment
Risk of bias will be assessed using Cochrane risk of bias tools
Strategy for data synthesis
A quantitative or narrative (descriptive) synthesis is planned
Analysis of subgroups or subsets
According to severity of ALI - ALI vs ARDS
Contact details for further information
Balwinder Singh
Mayo clinic
200 1st Street SW
Rochester
Minnesota- 55905
USA
singh.balwinder@mayo.edu
Organisational affiliation of the review
None
Review team
Dr Balwinder Singh, Mayo Clinic, Minnesota, USA Dr Pablo Moreno Franco, Mayo Clinic, Florida, USA Dr Akhilesh Tiwari, St. Stephen's Hospital, Delhi, India
Formal screening of search results against eligibility criteria
Data extraction
Risk of bias (quality) assessment
Data analysis
Prospective meta-analysis
PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites.
