Review question(s)
What are the long-term effects of low-fat vs. high-fat diets on blood lipids?
Searches
MEDLINE
EMBASE
Cochrane Central Register of Controlled Trials (CENTRAL)
no restriction (i.e. language, publication period- to July 2012)
restriction (randomized controlled trials)
Link to search strategy
Types of study to be included
Randomized controlled trials.
Condition or domain being studied
Primary prevention of cardiovascular disease.
Cardiovascular risk factors.
Participants/ population
Inclusion cirteria: overweight, obese, healthy, glucose intolerance, diabetes mellitus type 2.
Exclusion criteria: secondary prevention (existing coronary heart disease), participants age: <18 years
Intervention(s), exposure(s)
Inclusion criteria:
randomized controlled trial
duration >=12 months
low fat (<=30% fat of total energy content)
outcomes: total-cholesterol, LDL-cholesterol, HDL-cholesterol, triacyglycerols, ratio TC:HDL-C
Exclusion criteria:
secondary prevention (existing coronary heart disease), participants age: <18 years
Comparator(s)/ control
nclusion criteria:
randomized controlled trial
duration >=12 months
high fat diet (>30% fat of total energy content)
Outcomes: total-cholesterol, LDL-cholesterol, HDL-cholesterol, triacyglycerols, ratio TC:HDL-C
Exclusion criteria: secondary prevention (existing coronary heart disease), participants age: <18 years
Outcome(s)
Primary outcomes Total-cholesterol, LDL-cholesterol, HDL-cholesterol, triacyglycerols, ratio TC:HDL-C
Secondary outcomes None.
Risk of bias (quality) assessment
Strategy for data synthesis
Quantitative synthesis: means of post values or differences in means with their standard deviation of the intervention and controls;
random effect meta-analysis;
random effect meta-regression.
Analysis of subgroups or subsets
We performed subgroup analysis:
high-fat diets were differentiated to: control, low carbohydrate, low glycemic index/load, high protein and monounsaturated fat diets.
Contact details for further information
Lukas Schwingshackl
Althanstrasse 14
1090 Vienna
Department of Nutritional Sciences
Faculty of Life Sciences
lukas.schwingshackl@univie.ac.at
Organisational affiliation of the review
University of Vienna
www.univie.ac.at
Review team
Mr Lukas Schwingshackl, University of Vienna
Anticipated or actual start date
Anticipated completion date
Funding sources/sponsors
Conflicts of interest
Language
Country
Subject index terms status
Subject indexing assigned by CRD
Subject index terms
Blood; Diet, Fat-Restricted; Diet, High-Fat; Humans; Lipids
Date of registration in PROSPERO
Date of publication of this revision
Stage of review at time of this submission Started
Completed
Preliminary searches
No
Yes
Piloting of the study selection process
No
Yes
Formal screening of search results against eligibility criteria
No
Yes
Data extraction
No
Yes
Risk of bias (quality) assessment
No
Yes
Data analysis
No
Yes
Prospective meta-analysis
No
Yes
