Twelve RCTs (n=599) were included in the review.
The quality of the included trials was moderate (mean quality score 37.6, range: 33.5 to 41; maximum possible score 69).
Exercise.
Six of 6 trials demonstrated a benefit from therapeutic exercise programmes. Benefits in terms of shoulder function, pain and disability were observed when exercise was compared with placebo or no intervention. Benefits in comparison with surgery were unclear. The design of an optimal exercise programme, in terms of techniques, frequency, intensity and level of supervision, was unclear.
Joint mobilisation.
Two of 2 trials suggested that joint mobilisation combined with therapeutic exercise might lead to better outcomes. However, it was unclear which patients are most likely to respond to this combination and the exact techniques to be used were also unclear.
Laser therapy.
The current evidence from 3 trials, although conflicting, suggested that low-level laser therapy is more beneficial than placebo when applied as a single intervention. However, no additional benefits on the outcomes of pain and improvement of function were demonstrated when laser therapy was added to exercise.
Ultrasound.
Neither of the 2 trials investigating ultrasound demonstrated a beneficial effect in this patient group.
Acupuncture.
Evidence on acupuncture from 2 trials was limited and conflicting. One trial demonstrated no benefits of acupuncture over other treatments, whilst the other demonstrated short-term benefits only for pain, function and range of motion.