Seventy-two RCTs were included. The total number of participants involved was neither reported nor calculable. The numbers included in the meta-analyses are reported below.
Fifty RCTs scored 3 points out of a maximum of 5 for quality, 21 scored two points and one scored 1 point.
Seventy-four per cent of all studies (i.e. 53 out of 72) showed an effect with motivational interviewing. None of the studies reported any adverse effects of motivational interviewing, but none explicitly aimed to assess adverse effects. A higher percentage of studies reported effects for: encounters of 60 minutes compared with less than 20 minutes (81% versus 64%); more than five encounters compared with one encounter (87% versus 40%); at least 12 months compared with 3 months of follow-up (81% versus 36%); psychologists or medical doctors compared with others (79% and 83% versus 46%).
Motivational interviewing showed an effect in: 75% of studies (i.e. 35 out of 47) that focused on alcohol abuse, psychiatric diagnoses and addiction; 72% (i.e. 18 out of 25) of those that focused on physiological problems; 67% (i.e. 8 out of 12) of those that focused on smoking cessation alone; and 77% (i.e. 10 out of 13) of those that focused on asthma, diabetes and weight. A similar proportion of studies using direct and indirect measures reported an effect (75% versus 74%).
The funnel plot was judged to show no evidence of publication bias.
Nineteen studies provided sufficient data for inclusion in a meta-analysis. The meta-analysis showed a significant effect for the following outcomes: BMI (6 RCTs, n=1,140; effect size 0.72, 95% CI: 0.33, 1.11, P=0.0001), total blood cholesterol (3 RCTs, n=1,358; effect size 0.27 mmol/L, 95% CI: 0.20, 0.34, P=0.0001), systolic blood-pressure (2 RCTs, n=316; effect size 4.22 mmHg, 95% CI: 0.23, 8.99, P=0.038), blood alcohol concentration (6 RCTs, n=278; effect size 72.92 mg%, 95% CI: 46.80, 99.04, P=0.0001) and standard ethanol content (7 RCTs, n=648; effect size 14.64 standard units, 95% CI: 13.73, 15.55, P=0.0001).
There was no significant effect of motivational interviewing on cigarettes per day (3 RCTs, n=190) or HbA1c (4 RCTs, n=243).