The objectives of the review were clear. The supporting inclusion criteria were fairly broad. Appropriate sources were searched for relevant articles, but it did not appear that unpublished papers were searched. Articles were restricted by language. It is possible that publication and language biases may have been introduced. Studies were assessed on validity, but quality of the studies was generally weak to moderate, which impacts on the reliability of the conclusions. The process for assessment of validity was clear, but study selection and data extraction methods were not, so reviewer error and bias cannot be ruled out. Considering the methodological differences between the included studies, a narrative synthesis was appropriate. However, data on study characteristics were limited and few details on patient characteristics, such as age and co-morbidities, were reported. It is, therefore, unclear whether patients were comparable. The limitations with the included studies, particularly the poor quality of the studies and the small sample sizes, and the sometimes poor reporting of the review, meant that the authors' conclusions should be interpreted with caution and may not be reliable.