Six RCTs (n=2,086) and five prospective cohort studies (n=908) were included in the review. Sample sizes ranged from 10 to 1,127. PEDro scores ranged from 4 to 8.
Prevention of lateral ankle sprains (two RCTs, n=1,892 and one prospective cohort, n=814, but this may be an overestimate as it was unclear whether the same or different participants were included in the different year groups): Both RCTs reported that the intervention was associated with a significant reduction in the risk of ankle sprain in patients with a past history of ankle sprain, but there was no significant reduction in the risk of injury in patients with no past-history of ankle sprain. Relative risk reductions ranged from 20 per cent to 60 per cent. Numbers needed to treat ranged from 12 to 44. The prospective cohort reported a significant reduction in injury risk in year two of training, but not in year one.
Balance and co-ordination training for the treatment of acute ankle sprains (two RCTs, n=119 and one prospective cohort, n=48): One RCT and the cohort study reported no significant difference in postural control measures between trained and untrained groups. Three of four effect sizes from one RCT showed no significant difference in postural control measures between injured trained limbs and uninjured limbs.
Treatment of chronic ankle instability (two RCTs, n=75 and three prospective cohort studies, n=46): None of the studies provided sufficient data to permit calculation of relative risk reductions or numbers needed to treat. Studies reported mixed results for the effects of training versus no training on chronic ankle instability; results for some measures were significant and results for others were not significant.
Effect sizes were reported in the review. Many crossed zero. Thus, there may be uncertainly regarding the reliability of the reported findings.