Nineteen trials were included in the review (n=more than 13,029 children); 14 were randomised controlled trials (RCTs, n=>14,418 children) and five were non-randomized controlled trials (n=4,690 children); eight trials were included in the meta-analysis.
Eight trials assessed a combination of nutrition plus physical activity and found a significant reduction in body weight compared with control (standardised mean difference -0.29, 95% confidence interval (CI): -0.45 to -0.14; χ2=76.38, p<0.00001, I2=90.8%). Other interventions (nutrition and TV reduction) were each assessed in single trials and were also associated with a significant reduction in body weight compared with control. Physical activity was not associated with reduction in body weight (one trial).
Combination trials with a parent/family component were associated with improved body weight compared to control (standardised mean difference -0.20, 95% CI: -0.41 to 0.00; χ2=8.35, p =0.04, I2 =64.1%, four trials). This effect decreased when both a family and environmental component were included (standardised mean difference -0.16, 95% CI: -0.32 to 0.00; χ2=5.71, p=0.02, I2=82.5%, two trials).