Study found that bevacizumab, combined with interferon, and sunitinib have clinically relevant advantages over interferon alone in patients with metastatic renal cell carcinoma, temsirolimus has clinically relevant advantages over interferon in those with poor prognosis, and sorafenib tosylate is superior to best supportive care as second-line therapy, although none of the treatments was considered cost-effective at normal willingness to pay thresholds.