Study found that a pill-in-the-pocket (PiP) strategy seems to be slightly less effective than antiarrhythmic drug therapy and in-hospital treatment but is associated with cost savings. A change in clinical practice that includes the introduction of PiP may save costs but also involves a reduction in clinical effectiveness compared to existing approaches used to treat patients with paroxysmal atrial fibrillation (PAF); however, there is insufficient evidence to support a recommendation for the use of PiP strategy in patients with PAF