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Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia: a systematic review and economic evaluation |
Loveman E, Cooper K, Bryant J, Colquitt JL, Frampton GK, Clegg A |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Loveman E, Cooper K, Bryant J, Colquitt JL, Frampton GK, Clegg A. Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia: a systematic review and economic evaluation. Health Technology Assessment 2012; 16(23): 1-138 Authors' conclusions Report identifies limited new information on the clinical effectiveness of dasatinib, nilotinib and high-dose imatinib for the treatment of people with chronic myeloid leukaemia (CML) who are resistant to standard-dose imatinib, but suggests that the interventions can lead to improvements in haematological and cytogenetic responses in people with imatinib-resistant CML. Indexing Status Subject indexing assigned by NLM MeSH Antineoplastic Agents /economics /therapeutic use; Benzamides; Confidence Intervals; Cost-Benefit Analysis; Dasatinib; Disease Progression; Drug Resistance; Drug Therapy, Combination; Great Britains; Imatinib Mesylate; Kaplan-Meier Estimate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive /drug therapy /economics; Models, Economic; Piperazines /economics /therapeutic use; Protein Kinase Inhibitors /economics /therapeutic use; Pyrimidines /economics /therapeutic use; Quality-Adjusted Life Years; Thiazoles /economics /therapeutic use; Treatment Outcome Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32011000773 Date abstract record published 15/06/2011 |
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