Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Watchful dosing of morphine or morphine equivalent dosing in the treatment of chronic non-cancer pain: a review of the clinical evidence. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2012 Authors' conclusions The evidence base around a watchful dose threshold for morphine or equivalent opioid dosing was limited in both quality and quantity.
The evidence to support a watchful dose of morphine or morphine equivalent opioid dosing of greater than 200 mg/day in chronic non-cancer pain (CNCP) is limited in both quality and quantity; however, there is also little evidence to support a lower threshold dose.
The paucity of evidence for watchful dosing is likely reflective of larger gaps in evidence in the topic of CNCP management in general, including around the appropriate use of opioids.
Indexing Status Subject indexing assigned by CRD MeSH Analgesics, Opioids; Chronic Pain; Dose-Response Relationship, Drug; Morphine Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs and Technologies in Health (CADTH), 865 Carling Avenue, Suite 600, K1S 5S8 Ottawa, Ontario Canada Email: htainfo@cadth.ca AccessionNumber 32012000679 Date abstract record published 28/09/2012 |