Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Nicolau I, Pan I, Xie X, McGregor M, Dendukuri N. Drotrecogin alfa (Activated) in severe sepsis: a systematic review of observational studies (Update of Report 29) Montreal: Technology Assessment Unit of the McGill University Health Centre (MUHC). Report number: 58. 2012 Authors' conclusions • The mortality rates reported in the observational studies we reviewed, were higher than the rates previously reported
in RCTs (PROGRESS and ADDRESS).
• Studies that included a comparison group of patients not treated with DrotAA, generally concluded that there was a
beneficial effect of DrotAA treatment.
• The majority of studies reported being supported by the manufacturer. Indexing Status Subject indexing assigned by CRD MeSH Anti-Infective Agents; Humans; Protein C; Recombinant Proteins; Sepsis Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Technology Assessment Unit of the MUHC, Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve, Bureau 3F.50, Montreal, Quebec H4A 3S5 Email: nandini.dendukuri@mcgill.ca AccessionNumber 32012000901 Date abstract record published 28/11/2012 |