Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Belinson S, Chopra R, Yang Y, Shankaran V, Aronson N. Local hepatic therapies for metastases to the liver from unresectable colorectal cancer
. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 93. 2012 Authors' objectives To characterize the comparative effectiveness and harms of various local hepatic therapies for metastases to the liver from unresectable colorectal cancer (CRC) in two distinct populations: patients with liver-dominant metastases (i.e., majority of disease located in the liver) who are not eligible for continued systemic chemotherapy because their disease is refractory (i.e., they have experienced disease progression while on therapy), and patients who are candidates for local liver therapies as an adjunct to systemic chemotherapy. Local hepatic therapies include ablation, embolization, and radiotherapy approaches. Authors' conclusions In the absence of comparative data, the evidence is insufficient to permit conclusions on the comparative effectiveness of these therapies for unresectable CRC metastases to the liver. Gaps in the research base, even for critical benefits or harms, are extensive, and the quality of studies is generally questionable. Conducting RCTs (ideally head-to-head comparisons) to answer many important questions is desirable, but challenging. Indexing Status Subject indexing assigned by CRD MeSH Catheter Ablation; Colorectal Neoplasmss; Combined Modality Therapy; Embolization, Therapeutic; Liver Neoplasms; Neoplasm Metastasis Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence AHRQ, Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA Email: AHRQTAP@ahrq.hhs.gov AccessionNumber 32013000239 Date abstract record published 17/04/2013 |