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Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery |
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Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Seprafilm adhesion barrier (Genzyme Corp.) for prevention of abdominal adhesions after gynecologic surgery. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2012 Authors' conclusions After intra-abdominal operations, more than 90% of patients develop adhesions. Obstetric and gynecologic surgical procedures such as Cesarean delivery, abdominal hysterectomy, myomectomy, ovarian cystectomy, and surgeries for invasive gynecologic malignancies have a particularly high propensity for development of postoperative adhesions. Adhesion-related complications often require readmission and repeat surgery. In 2005, more than 350,000 surgical
procedures were performed in the United States for lysis of adhesions, with an economic impact exceeding $2.3 billion. Adhesion-related complications following obstetric and gynecologic procedures include small bowel obstruction, infertility, recurrent pelvic pain, and difficult reoperative surgery. Basic preventive strategies involve minimizing surgical trauma by using appropriate techniques and instrumentation, opting for the least invasive technique, and avoiding the introduction of foreign materials into the abdominal cavity. A second approach involves the use of systemic and intraperitoneal pharmacological agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, agents targeting the plasmin cascade, and hormones. A third approach involves a number of liquid- and solid-phase agents (membranes, sheets) that primarily act as barriers between two adjacent peritoneal surfaces. Indexing Status Subject indexing assigned by CRD MeSH Abdomen; Gynecologic Surgical Procedures; Humans; Postoperative Complications; Tissue Adhesions Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32013000282 Date abstract record published 23/04/2013 |
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