Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Bone morphogenetic proteins for use in spinal surgery and long bone trauma surgery: a review of the clinical effectiveness and safety. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary with Critical Appraisal. 2013 Authors' conclusions The evidence presented in this report supports the use of rhBMP-2 in posterolateral lumbar fusion (PLF) and posterior lumbar interbody fusion (PLIF) as some outcomes may be superior to that of autograft alone. There are no statistically significant differences in clinical effectiveness outcomes for rhBMP-2 use in the treatment of long bone nonunion yet there is some limited evidence that rhBMP-2 use has the possible advantages of significantly less treatment failure and fewer secondary interventions for treatment of tibial fractures. Although the evidence reviewed in this report does not directly compare rhBMP-2 with rhBMP-7, it does provide more support for the use of rhBMP-2 in spinal fusion surgeries and the treatment of long bone nonunion. There is limited evidence to suggest serious acute adverse events following the use of BMPs in cervical spinal fusion surgeries. There was limited evidence of a significant increase in the incidence of retrograde ejaculation (RE) following anterior lumbar interbody fusion (ALIF) surgery using BMPs. This report also finds a significant evidence gap regarding an association between cancer incidence and BMP exposure. Indexing Status Subject indexing assigned by CRD MeSH Bone Morphogenetic Proteins; Fractures, Bone; Fractures, Ununited; Humans; Spinal Fusion Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs and Technologies in Health (CADTH), 865 Carling Avenue, Suite 600, Ottawa, Ontario Canada, K1S 5S8 Email: requests@cadth.ca AccessionNumber 32014000203 Date abstract record published 29/01/2014 |