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Acido hialurónico intra-articular para artrosis de rodilla [Intra-articular use of hyaluronic acid in the treatment of knee osteoarthritis] |
Pichon Riviere A, Augustovski F, Garcia Marti S, Alcaraz A, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Ciapponi A |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Garcia Marti S, Alcaraz A, Glujovsky D, Lopez A, Rey-Ares L, Bardach A, Ciapponi A. Acido hialurónico intra-articular para artrosis de rodilla. [Intra-articular use of hyaluronic acid in the treatment of knee osteoarthritis] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rápida N° 305. 2013 Authors' objectives To assess the available evidence on the efficacy, safety and coverage policy related aspects regarding the use of intra-articular hyaluronic acid in patients with knee osteoarthritis. Authors' conclusions The evidence found is of high methodological quality. The studies found show that intra-articular hyaluronic acid, when used in patients with knee osteoarthritis who have not responded to non-pharmacological treatments and pharmacological treatments with simple analgesics, slightly reduces pain and improves mobility compared with placebo, analgesics or intra-articular corticosteroids, in the 3-6 month evaluated period. There is still not enough information published stating if repeated use is better than a single-dose, or if the benefit showed persists at a longer term. Also, there was no evidence found on the effectiveness, as a single or repeated doses, in relation to stopping osteoarthritis progression, or if it reduces the likelihood of requiring joint replacement. Most Clinical Practice Guidelines and Health Sponsors consulted agree to cover HA for knee OA which has not responded to non-pharmacological and pharmacological treatments. They do not mention if its use is covered as single or repeated doses. More studies assessing the evolution of single and repeated doses at a longer term are needed to reach better conclusions. Indexing Status Subject indexing assigned by CRD MeSH Hyaluronic Acids; Osteoarthritis, Knee Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32014000258 Date abstract record published 28/01/2014 |
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