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Terapia con Insulina Detemir en poblaciones pediátricas y embarazadas [Insulin Detemir therapy in pediatric and pregnant population] |
Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Meza V |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Meza V. Terapia con Insulina Detemir en poblaciones pediátricas y embarazadas. [Insulin Detemir therapy in pediatric and pregnant population] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rápida N° 287. 2012 Authors' objectives The purpose of this report is to evaluate the evidence available on the efficacy, safety and coverage related policies aspects for the use of Insulin Detemir for the treatment of Diabetes Mellitus in children, adolescents and pregnant women. Authors' conclusions Evidence of high methodological quality was identified. The efficacy of Insulin Detemir in children and adolescents with Type 1 DM is similar to that of NPH (baseline insulin) in terms of HBA1c decrease. Based on the information reported by two RCTs and several observational studies, the evidence shows that Insulin Detemir might have only a slightly better profile in relation to risks of hypoglycemia. For these reasons and because the insulin analogues are very expensive, they are not considered standard therapies; they are used in special situations such as lack of metabolic control or frequent occurrence of nocturnal or severe episodes of hypoglycemia, where a lower number of administrations might be required. Several European health systems recommend the use of NPH insulin during pregnancy because it helps to better adjust the response to a variable calorie intake and the insulin-sensitivity in pregnant women. The available information on insulin detemir is not enough to recommend its routine use as substitute of NPH during pregnancy. Indexing Status Subject indexing assigned by CRD MeSH Child; Child, Preschool; Hypoglycemia; Hypoglycemic Agents; Insulin; Pregnancy in Diabetics Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32014000277 Date abstract record published 28/01/2014 |
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