|
Antiplatelet and anticoagulant treatments for unstable angina/non–ST elevation myocardial infarction |
Melloni C, Jones WS, Washam JB, Hasselblad V, Mayer SB, Halim S, Subherwal S, Alexander K, Kong DF, Heidenfelder BL, Irvine RJ, Wing L, Dolor RJ |
|
|
Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Melloni C, Jones WS, Washam JB, Hasselblad V, Mayer SB, Halim S, Subherwal S, Alexander K, Kong DF, Heidenfelder BL, Irvine RJ, Wing L, Dolor RJ. Antiplatelet and anticoagulant treatments for unstable angina/non–ST elevation myocardial infarction. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 129. 2014 Authors' objectives For patients with unstable angina or non–ST elevation myocardial infarction (UA/NSTEMI), antiplatelet and anticoagulant medications are prescribed to reduce and prevent ischemic events and mortality. There is uncertainty about the optimal dosing and timing of these medications to balance ischemic risk and bleeding risk across different treatment strategies (early invasive, initial conservative, and postdischarge). Authors' conclusions The number of studies available for each comparison was relatively small, and the preponderance of observational studies made the findings for some comparisons inconclusive. Further study is needed to determine the effectiveness and safety of newer agents in combination with other antiplatelet and anticoagulant strategies. Uncertainty remains about the optimal dosing, timing, duration, and combinations of these options, especially in subpopulations of interest (e.g., the elderly, patients with diabetes, women, obese patients, and people with comorbid illness). Indexing Status Subject indexing assigned by CRD MeSH Angina, Unstable; Anticoagulants; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence AHRQ, Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA Email: AHRQTAP@ahrq.hhs.gov AccessionNumber 32014000520 Date abstract record published 29/05/2014 |
|
|
|