Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. The appropriate use of neuroimaging in the diagnostic work-up of dementia: an evidence-based analysis. Toronto: Health Quality Ontario (HQO). Ontario Health Technology Assessment Series (OHTAS) 14(1). 2014 Authors' conclusions With the exception of dementia related to vascular disease, prevalence of potentially treatable dementias is low (< 10%), and improvement after treatment of the underlying condition is less than 1% (GRADE: Very low).
Prediction rules and individual clinical indications do not reliably predict abnormalities or influence diagnosis or treatment (GRADE: Very low).
The clinical utility of structural neuroimaging is:
high for patients with potentially mixed dementia
high for patients where there is uncertainty for 2 years or more about the type of dementia
low for patients with Alzheimer disease clinically diagnosed by follow-up over time (e.g., 1 year)
low for patients where vascular dementia has been clinically excluded (GRADE: Low)
For the detection of a vascular component to dementia, there is a lack of evidence that MRI is superior to CT (GRADE: Low).
In terms of diagnostic accuracy, structural neuroimaging has low to moderate sensitivity and high specificity for discriminating Alzheimer disease, Creutzfeldt-Jakob disease, and clinically ambiguous cases (GRADE: Low to Very low). Indexing Status Subject indexing assigned by CRD MeSH Dementia; Diagnosis, Differential; Neuroimagings Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5 Email: EDSinfo@hqontario.ca AccessionNumber 32014000651 Date abstract record published 23/06/2014 |