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Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18- to 64-year-olds |
Nicholson KG, Abrams KR, Batham S, Medina MJ, Warren FC, Barer M, Bermingham A, Clark TW, Latimer N, Fraser M, Perera N, Rajakumar K, Zambon M |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Nicholson KG, Abrams KR, Batham S, Medina MJ, Warren FC, Barer M, Bermingham A, Clark TW, Latimer N, Fraser M, Perera N, Rajakumar K, Zambon M. Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18- to 64-year-olds. Health Technology Assessment 2014; 18(36): 1-138 Authors' objectives To determine the diagnostic accuracy and clinical effectiveness and cost-effectiveness of
rapid molecular and near-patient diagnostic tests for influenza, respiratory syncytial virus (RSV) and
Streptococcus pneumoniae infections in comparison with traditional laboratory culture. Authors' conclusions All tests had limitations. We found no evidence that POCTs for influenza or S. pneumoniae,
or PCR for influenza or RSV influenced antimicrobial prescribing or clinical outcomes. The total costs and
QALYs of each diagnostic strategy were similar, although, incrementally, PCR was the most cost-effective
strategy. The analysis does not support routine use of POCTs for either influenza or pneumococcal antigen
for adults presenting with acute cardiopulmonary conditions, but suggests that conventional viral culture
for clinical diagnosis should be replaced by PCR. Indexing Status Subject indexing assigned by CRD MeSH Influenza, Human; Respiratory Syncytial Viruses; Streptococcus pneumoniaes Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32014000664 Date abstract record published 24/06/2014 |
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