Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Schaink A. The effectiveness of statins for primary prevention: a rapid review. Toronto: Health Quality Ontario (HQO). Rapid Review. 2013 Authors' objectives The objective was to determine the effectiveness of statins in avoiding downstream adverse clinical outcomes associated with dyslipidemia, specifically major coronary events and stroke. Authors' conclusions Three meta-analyses examining the effectiveness of statins for primary prevention were identified. Due to superior methodological quality and stringent criteria on exclusion of participants with a previous history of CVD, the meta-analysis by Taylor et al (10) was selected as the primary review to answer the research question, while the other 2 provided additional context.
Statins significantly reduced the risk of major coronary events (i.e., combined fatal and nonfatal coronary events) in individuals without a previous history of CVD, compared to placebo. (GRADE quality of evidence: moderate)
The risk of stroke (fatal and nonfatal) was significantly reduced in individuals without a previous history of CVD treated with statins, compared to placebo. (GRADE quality of evidence: low)
The direction and magnitude of reduction in both major coronary events and stroke events was consistent across all 3 meta-analyses, despite differences in the definition of primary prevention populations. Indexing Status Subject indexing assigned by CRD MeSH Hydroxymethylglutaryl-CoA Reductase Inhibitorss; Primary Prevention Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5 Email: EDSinfo@hqontario.ca AccessionNumber 32014001037 Date abstract record published 09/09/2014 |