Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Lux LJ, Posey RE, Daniels LS, Henke DC, Durham C, Jonas DE, Lohr KN. Pharmacokinetic/pharmacodynamic measures for guiding antibiotic treatment for hospital acquired pneumonia. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 136. 2014 Authors' objectives To conduct a systematic review of the use of pharmacokinetic/pharmacodynamic (PK/PD) measures or strategies to dose and monitor intravenous (IV) antibiotics in the treatment of adults with hospital-acquired pneumonia (HAP). Authors' conclusions In the setting of increasing antimicrobial resistance worldwide and limited new antibiotics in the pipeline, optimizing dosing with PK/PD strategies could serve as an important antimicrobial stewardship tool to improve the use of currently available antibiotics. While PK/PD dosing strategies are supported by concept, the lack of prospective patient outcome data leaves clinicians with little guidance on how to best apply these principles to patient care. This review highlights the significant need for additional research to illuminate the role of antibiotic PK/PD dose optimization for the treatment of HAP. Indexing Status Subject indexing assigned by CRD MeSH Anti-Bacterial Agentss; Cross Infection; Pneumonia Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence AHRQ, Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA Email: AHRQTAP@ahrq.hhs.gov AccessionNumber 32014001422 Date abstract record published 11/12/2014 |