Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Obesity management interventions delivered in primary care for patients with osteoarthritis: a review of clinical effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response. 2014 Authors' conclusions Dietary weight loss interventions, either alone or in combination with exercise produced greater reductions in the peak knee compressive force and plasma levels of interleukin-6 (IL-6) in knee OA patients compared with exercise-induced weight loss. Significantly greater reduction in pain and improvements in functions were reported in patients who received diet plus exercise interventions compared with either dietonly or exerciseonly interventions. Regardless of group assignment, participants who lost 10% or more of baseline body weight had greater reductions in knee compressive force, systemic IL-6 concentrations, and pain, as well as gained greater improvement in function than those who lost less of their baseline weight. However, participants who lost the most weight also experienced greater loss of bone mass density at the femoral neck and hip, but not the spine, without a significant change of their baseline clinical classification with regards to osteoporosis or osteopenia. Findings from a cohort study suggest that patients with hip osteoarthritis could achieve weight loss associated with significant improvement in their physical function, mobility, and pain scores. Indexing Status Subject indexing assigned by CRD MeSH Humans; Obesity; Osteoarthritis; Primary Health Care Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Canadian Agency for Drugs and Technologies in Health (CADTH), 865 Carling Avenue, Suite 600, Ottawa, Ontario Canada, K1S 5S8 Email: requests@cadth.ca AccessionNumber 32015000219 Date abstract record published 05/03/2015 |