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Determinación del índice de proliferación Ki-67 en pacientes con cáncer de mama temprano [Ki-67 proliferative index in patients with early breast cancer] |
Gonzalez L, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Gonzalez L, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A, López A, Rey-Ares L. Determinación del índice de proliferación Ki-67 en pacientes con cáncer de mama temprano. [Ki-67 proliferative index in patients with early breast cancer] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No, 419. 2015 Authors' conclusions The evidence supporting Ki-67 proliferative index as prognostic factor in women with early breast cancer is of moderate methodological quality. This is based on the retrospective analysis of selected and heterogeneous samples of patients, which suggest that a high index would be associated with higher chances of recurrence and death due to breast cancer.
The results on its ability to predict the benefit of adjuvant chemotherapy in those patients with high index come from low methodological quality studies which also show contradictory results.
There is no consensus among the main international societies on its systematic use in patients with early breast cancer. Not having a defined cut-off value to determine an index as high or studies assessing changes in treatment decision making and its subsequent clinical impact, limit its recommendation.
Indexing Status Subject indexing assigned by CRD MeSH Breast Neoplasms; Humans; Ki-67 Antigen Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32015001150 Date abstract record published 12/11/2015 |
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