Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Quality Ontario. Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 15(16). 2015 Authors' conclusions Islet transplantation offers an alternative for patients with type 1 diabetes who have brittle diabetes with difficult-to-control blood glucose levels or hypoglycemic unawareness despite optimal insulin therapy. Treatment depends on patient eligibility and is influenced by donor islet availability, technical limitations of the procedure, and immunosuppression protocols.
In non-uremic patients, compared with (a) status prior to islet transplantation or (b) intensive insulin therapy, islet transplantation alone generally:
• Improves glycemic control (GRADE: low to high)
• Improves secondary complications for diabetes (GRADE: very low to low)
• Increases procedure-related and immunosuppression-related adverse events (GRADE: low)
• Improves health-related quality of life (GRADE: very low)
In uremic patients, compared with (a) status prior to islet transplantation or (b) intensive insulin therapy, simultaneous islet-kidney transplantation and islet-after-kidney transplantation generally:
• Improve glycemic control (GRADE: low to high)
• Improve secondary complications for diabetes (GRADE: low)
• Increase procedure-related and immunosuppression-related adverse events (GRADE: low)
• Improve health-related quality of life (GRADE: very low)
Additional long-term comparative studies are required for a better understanding of the continuing effects of transplanted islets and the immunosuppression protocols used.
Ontario Indexing Status Subject indexing assigned by CRD MeSH Diabetes Mellitus, Type 1; Humans; Islets of Langerhans Transplantation; Pancreas Transplantation Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5 Email: EDSinfo@hqontario.ca AccessionNumber 32015001201 Date abstract record published 08/12/2015 |