Study designs of evaluations included in the review
Randomised controlled trials (RCTs) ranging in treatment duration from 3 to 5 days.
Specific interventions included in the review
Proton pump inhibitors (PPIs) (omeprazole (either 80 mg bolus, then 40 mg IV every 8 hours for 24 hours then 40 mg orally every 12 hours, or 80 mg bolus then 40 mg IV every 12 hours or every 8 hours, or 40 mg bolus then 6.7 mg/hour IV, or 40 mg orally every 12 hours)) for the intervention group and placebo or ranitidine (50 mg IV every 4 hours or 6 hours) or cimetidine (50 mg/hour IV) in the control groups.
Participants included in the review
Hospitalised patients with endoscopically documented bleeding peptic ulcers.
Outcomes assessed in the review
Incidence of rebleeding for the categories of spurting, oozing, non- bleeding visible vessel (NBVV), clot, and all categories.
How were decisions on the relevance of primary studies made?
The authors do not state how the papers were selected for the review, or how many of the authors performed the selection.