Twenty studies were included (at least 33, 229 children; the number of families was reported for some studies). These comprised 16 RCTs, 3 CBAs and a controlled trial.
Among the 16 RCTs, three reported adequate allocation concealment, fifteen reported baseline data for the primary outcome, nine reported adequate follow-up, eight reported blinded outcome assessment, six reported the same unit of allocation and analysis, three were judged as being at risk of contamination and fourteen used intention-to-treat analysis. Among the 4 non-RCTs, three reported baseline data for the primary outcome, two reported blinded outcome assessment, three reported adequate follow-up and one reported the same unit of allocation and analysis, and all four used appropriate matched controls.
Primary school (4 studies).
Tobacco, alcohol and drug use (1 study): this study reported no significant difference between the intervention and control in substance use.
Tobacco use (2 studies): both studies reported significant reductions in smoking in children exposed to the intervention compared with control.
Alcohol use (1 study): this study reported a significant reduction in alcohol use and misuse among children exposed to the intervention who had not previously used alcohol compared with control, but a significant increase in use and misuse among children already using alcohol at baseline.
Transition between primary and secondary school (8 studies).
Tobacco, alcohol and drug use (4 studies): all 4 studies reported reduced tobacco, alcohol and drug use in children exposed to the intervention compared with control. In 3 studies, reductions for all three types of use were significantly reduced; in the third study reductions were only significant for drugs and tobacco misuse.
Tobacco use (1 study): this study reported no significant difference between the intervention and control in smoking.
Alcohol use (3 studies): all 3 studies reported reduced alcohol use among children exposed to the intervention compared with control. The reduction was statistically significant in one study, while in another the reduction was significant only in one type of school.
Adolescents (8 studies).
Tobacco, alcohol and drug use (3 studies): one study reported significant reductions in all types of substance use in children exposed to the intervention; one study reported a statistically significant reduction in alcohol, drug and tobacco use with the intervention among boys only; and one study reported no difference between the intervention and control in drug use or smoking, but an increase in alcohol use.
Drugs and tobacco (1 study): this study targeted drugs and chewing tobacco, and reported no significant difference between the intervention and control in drug use.
Alcohol and tobacco (1 study): this study reported a significant reduction in smoking onset in children exposed to the intervention compared with control, but no significant difference between interventions in alcohol use.
Tobacco (2 studies): one study reported significantly reduced smoking among children exposed to the intervention compared with control; the other study reported that the intervention was associated with a statistically significant reduction in smokeless tobacco use, but a significant increase in smoking.
Alcohol (1 study): this study reported a significant reduction in alcohol use in children exposed to the intervention compared with control.