Seven RCTs (n=601) were included in the review; response rates were available in 6 studies (n=552).
Two trials explicitly stated the method used to define the response rates.
No statistically significant between-group differences were found for overall response rate (RR 1.07, 95% CI: 0.97, 1.18; 6 RCTs, n=552). A greater effect, in favour of amifostine, was found with the exclusion of the largest trial (RR 1.62, 95% CI: 0.97, 2.73) but this was not statistically significant. No statistically significant between-group differences were found for complete response rate (RR 1.21, 95% CI: 0.83, 1.78; 6 RCTs, n=552) or partial response rate (RR 0.99, 95% CI: 0.78, 1.26; 6 RCTS, n=552). The sensitivity analyses did not significantly alter these findings. There was no evidence of statistical heterogeneity.