Nine studies were included in the review (280 patients, study size ranged from five to 88). The majority did not meet recommendations on study quality. The authors stated that there was substantial heterogeneity present, but this was not formally assessed.
Two of the three studies evaluating peridontal defects reported a significant improvement with platelet-rich plasma. Both studies evaluating sinus elevations showed a significant difference between platelet-rich plasma and controls. Two of the three studies evaluating oral-maxillofacial reconstructions reported positive effects of platelet-rich plasma. Only one study evaluated bone formation in extraction sites and reported a positive result.