Randomised controlled trials (RCTs) that compared PTFE with Dacron grafts for peripheral vascular bypass surgery were eligible for inclusion.
The primary review outcome was primary patency as defined by the primary study authors. Secondary outcomes were secondary patency, graft infection rates, limb salvage and amputation rates, and perioperative (<30 days) mortality. Most studies defined primary patency as unassisted/uninterrupted patency with no follow-up procedures on the bypass assessed by objective methods; one study defined primary patency as assisted primary patency.
Duration of follow-up ranged from two to eight years. Indications for surgery were disabling claudication, rest pain, tissue necrosis, tissue loss, indication for arterial graft of at least 20cm, aortoilliac occlusive disease and chronic lower limb ischaemia.
The authors did not state how studies were selected for the review.