Prospective controlled cohort studies of at least 10 patients treated with one of five growth factors with a minimum of three months follow-up were eligible for inclusion. Randomised controlled trials (RCTs) and cohort studies were included in the review. Only studies with a primary outcome of localised alveolar ridge augmentation diagnosed clinically, radiographically or histologically were eligible. All of the included studies were of BMP-2. The review included data from animal studies, which were outwith the scope of this abstract.
Mean age of patients in the included studies was 51.92 years (range 47.4 to 55). Patients were treated for extraction socket augmentation, sinus floor augmentation, ridge preservation or lateral ridge augmentation. Dose of BMP-2 ranged from ranged from 0.5mg/mL to 1.75mg/mL or 0.12mg/patient to 3.4mg/patient applied using a carrier of absorbable collagen sponge or demineralised bovine bone mineral (DBBM). Control groups received absorbable collagen sponge, a bone graft or nothing. The outcomes assessed were bone height, ridge height, ridge width, defect depth, new bone volume, new bone density, newly formed bone, % mineralised bone and DBBM contact with bone.
Two reviewers selected the studies for inclusion in the review . Discrepancies were resolved by consensus.