Eligible studies were double-blind sham controlled trials that applied at least five sessions of high-frequency (>5Hz rTMS with an intensity of >80% motor threshold) 45 degrees and 90 degrees from the scalp or sham coil over the left DLPFC of adults with major depressive episode without psychotic features according to DSM-IV criteria.
The primary outcome measures were: baseline corrected percentage change scores on the Hamilton Depression Rating Scale (HAMD) or the Montgomery-Asberg Depression Rating Scale (MADRS).
In most studies patients were treatment resistant and the HAMD score was used. Mean patient age (range 38.9 to 66.5 years), motor threshold (range 80% to 110%), pulses per session (range 250 to 3,000) and number of sessions (range 5 to 20) varied between studies.
The authors stated neither how papers were selected for the review nor how many reviewers performed the selection.