Prospective and retrospective clinical studies and case series that compared early and late pulp extirpation in adult permanent anterior teeth and that reported periodontal healing outcomes were eligible for inclusion. Outcomes were: acceptable and functional periodontal healing, replacement resorption and inflammatory resorption for pulp extirpation within 10 and within 14 days. Animal and laboratory studies or investigations of primary or permanent posterior teeth were excluded.
Included studies were retrospective clinical audits or prospective cohort studies conducted in populations aged between six and 48 years. Periodontal healing outcomes were assessed clinically and using radiographs, high percussion notes, reduced mobility, infraocclusion and periodontal ligament space loss. Follow-up ranged from up to one year to seven years.
One reviewer performed the study selection.