Twenty studies (n=3,170) were included in the review.
Clomiphene citrate challenge test (CCCT) (20 studies, n=3,170): Summary sensitivity was 27% (95% CI 24% to 30%) and summary specificity was 92% (95% CI 89% to 94%) in the seven studies that used similar thresholds to define a positive test result (FSH>10 IU/l on day three or 10). Estimates were similar when the analysis was restricted to the five studies that enrolled women who were undergoing assisted reproduction treatment. Other thresholds and populations were each assessed in one or two studies.
GnRH agonist stimulation test (GAST) (12 studies, n=1,179): There was insufficient data to be combined across studies.
Exogenous FSH ovarian reserve test (EFORT) (seven studies, n=430): There was insufficient data to be combined across studies.