Thirteen prospective randomised trials (n=1,161) were included in the meta-analysis.
Comparison of mini-CPB (n= 562) and C-CPB (n=599) clinical data found that patients in the mini-CPB group were statistically significantly older than those in the C-CPB group. No significant differences were found between the two groups for lower ventricular ejection fraction, duration of bypass procedure and aortic cross-clamping time.
Comparison of mini-CPB and C-CPB found no significant differences in rates of in-hospital mortality (13 studies), length of stay in the intensive care unit (11 studies) or resternotomy (four studies). There was a significant decrease in risk of postoperative stroke for mini-CPB compared to C-CPB (OR 0.25, 95% CI 0.06 to 1.00; 12 studies, n=1,061) and for postoperative blood loss (WMD -96.55, 95% CI -147.48 to -45.62; 10 studies, n=1,061). Analysis of postoperative blood loss and length of stay in the intensive care unit showed significant heterogeneity (I2=85%).
Subanalysis of isolated coronary artery bypass surgery procedures (n=1,021) found no significantly different results to the overall procedures.