Retrospective and prospective clinical trials that involved patients with a replanted avulsed permanent anterior tooth (conforming to contemporary clinical guidelines) who were prescribed SAT versus not prescribed SAT were eligible for inclusion in the review if they reported periodontal healing outcomes in relation to SAT. Animal and laboratory studies, intentional extraction, transplantation and avulsion studies were excluded.
Included periodontal healing outcomes were no root resorption, non-progressive root resorption, progressive resorption, periodontal healing, periodontal necrosis, positive (acceptable healing) and negative (inflammatory resorption, ankylosis/replacement resorption, marginal periodontal breakdown or extraction/progressive resorption) outcomes.
Included participants were aged between six and 52 years. Included specified SAT were penicillin and erythromycin. Follow-up ranged from two months to 40 years.
The authors did not state how many reviewers selected the studies.