All studies that evaluated the effect of lamina terminalis fenestration on the incidence of shunt-dependent hydrocephalus following aneurysmal sub-arachnoid hemorrhage were eligible for inclusion. Editorials, commentaries, case reports and reviews were excluded.
Most of the included studies enrolled patients with Fisher Grade 3 or 4 sub-arachnoid hemorrhage. Over half of the patients were female. Mean age was 51 years. The fenestrated and nonfenestrated groups varied significantly with regard to sex, age, clinical grade and aneurysm location. Most aneurysms were located in the anterior circulation (carotid arteries or its branches, anterior and middle cerebral arteries or anterior communicating artery, ACoA).
The authors did not state how many reviewers assessed studies for inclusion.