Four RCTs (n=404) were included in the review. Allocation concealment, intention-to-treat analysis and blinding of investigator/assessor were poorly reported in the studies. Overall, the methodological quality of the studies was considered to be inadequate.
In both fixed-effect and random-effects models, there was no statistically significant difference between skin adhesives and sutures for port-site wound closure in terms of wound infection (four RCTs), wound dehiscence (four RCTs) and patient satisfaction (two RCTs); no statistically significant heterogeneity was reported for any of the analyses.
Tissue adhesives were statistically quicker to use than sutures (fixed-effects SMD -1.66 seconds, 95% CI -1.90 to -1.43 and random effects SMD -2.13 seconds, 95% CI -3.27 to -1.00; four RCTs); this finding was associated with significant statistical heterogeneity (Q = 59.09, df = 3, p<0.000).