Six randomised trials (224 patients) and three non-randomised studies (192 patients) were retrieved, although only four trials were included in meta-analysis. Event rates for symptomatic intracerebral haemorrhage ranged from zero to 36%; and from zero to 64% for recanalisation.
There were no significant differences between ultrasound-enhanced thrombolysis and tPA alone for symptomatic intracerebral haemorrhage.
For complete recanalisation there was no significant difference between TCCD and tPA alone. TCD was significantly better than tPA alone (OR 3.70, 95% CI 1.95 to 7.0).
For functional independence tPA plus TCD was significantly better than tPA alone (OR 1.88, 95% CI 1.03 to 3.43). There was no difference with TCCD.