Clinical trials that assessed use of antioxidants in management of acute or chronic pancreatitis or prevention of pancreatitis were eligible for inclusion.
The included studies assessed one or more of the following at various doses and administered orally or intravenously: glutamine, curcumin, vitamin C, vitamin E, glutathione precursors, allopurinol, selenium, methionine, beta-carotene, alpha-tocopherol, N-acetylcysteine, S-adenosyl methionine (SAMe) and dimethyl sulphoxide. Control interventions included placebo, delayed treatment, standard total parenteral nutrition and lower-dose antioxidant. A broad variety of outcomes was assessed and included pain, use of analgesia, hospitalisation, infection, operation, mortality, morbidity, organ dysfunction, quality of life, physical and social functioning, health perception, cure rate, cost, prevention of pancreatitis, severity of pancreatitis and adverse events.
The authors did not state how studies were selected for inclusion.