Five studies (n=1,145) were included in the review: three RCTs (n=526) and two controlled trials (n=619). Sample sizes ranged from 53 to 566.
Treatment using the single stent approach was associated with significantly smaller postprocedural MLD of side branch (SMD -0.71, 95% CI -0.88 to -0.54; no heterogeneity) in comparison with the double stent approach.
There were no significant differences between single and double stent approaches for side-branch restenosis (significant heterogeneity, I2=76%), main-branch restenosis, all-cause mortality, myocardial infarction, TLR, postprocedural MLD of main branch (significant heterogeneity, I2=67%), and follow-up MLD of side branch and main branch (significant heterogeneity, I2=65%). Sensitivity analyses did not significantly alter the review findings.