Seven RCTs were included (n=1,521 patients). Duration of follow-up ranged from two to ten years.
Pooled cumulative patency rates at five years were 49.2% (95% CI 45.6 to 52.7) for Dacron grafts and 38.4% (95% CI 32.2 to 44.6) for polytetrafluoroethylene grafts.
There was no statistically significant difference in the risk of graft occlusion between Dacron and polytetrafluoroethylene grafts (HR 0.87, 95% CI 0.67 to 1.12; random-effects model). Significant heterogeneity was found (p=0.03).
After excluding the trial that used fluoropolymer coated Dacron, Dacron grafts were associated with a significant reduction in the graft occlusion with no significant heterogeneity (HR 0.75, 95% CI 0.63 to 0.89; fixed-effect model).
For patients with above-knee femoropopliteal bypass grafts, Dacron grafts were associated with a significant reduction in graft occlusion compared with polytetrafluoroethylene grafts (HR 0.71, 95% CI 0.57 to 0.89; three trials; fixed-effect model).
There was no evidence of significant publication bias from Egger’s test.