Ten studies (n=971,307 participants, range 504 to 729,529) were included in the analysis: one RCT (n=17,802) and nine observational studies (six case control, two retrospective cohort and one prospective cohort). The RCT was rated as good quality. Seven observational studies were rated as fair quality and two were rated as poor quality.
Statin use was associated with a significantly decreased risk of venous thromboembolism (adjusted OR 0.68, 95% CI 0.54 to 0.86); nine studies, n=845,445), a significantly decreased risk of DVT (adjusted OR 0.59, 95% CI 0.43 to 0.82) five studies, n=234,730) and a significantly decreased risk of pulmonary embolism, (adjusted OR 0.70, 95% CI 0.53 to 0.94; four studies, n=108,868). Results were similar for all subgroup analyses. Heterogeneity was high in all analyses (I2=67% to 89%).
The funnel plot and Egger’s weighted regression statistic suggested a low likelihood of publication bias.