Five trials were included in the review (n=1,195 women, range 79 to 588). There were 303 women in the radical vaginal trachelectomy groups and 892 women in the hysterectomy groups.
There was no significant difference between the groups in five-year progression-free survival rate (RR 0.99, 95% CI 0.95 to 1.02; four trials; I2=0%) or five-year overall survival rate (RR 0.97, 95% CI 0.93 to 1.02; three trials; I2=27%).
Findings on the operation time were inconsistent. Two trials found that radical vaginal trachelectomy took significantly longer, while two found no significant difference between the groups.
Radical vaginal trachelectomy was associated with a shorter hospital stay (four trials), lower blood loss (three of four trials) and lower likelihood of blood transfusion (RR 0.33, 95% CI 0.12 to 0.90; five trials; I2=72%; random-effects model). There was no significant difference between the groups in the rate of intraoperative complications (five trials) or postoperative complications (four trials).