The cost of identifying metastatic disease through a staging bone scan was $39,685 per patient. The cost per asymptomatic patient with bone metastases was $277,798. The routine follow-up bone scans cost $92,430 and prompted $12,039 worth of additional studies. The cost of detecting metastatic bone disease via routine follow-up bone scans was $14,924 per cancer recurrence identified or $104,469 per asymptomatic patient during this 2 year period.