At 3 to 4 months, the mean serum cholesterol was 4.10 mmol/L (standard deviation, SD=0.73) with atorvastatin compared with 4.07 mmol/L (SD=0.55) with simvastatin, (p=0.66). At 10 months, none of the patients had had a new diagnosis of ischaemic heart disease or cerebrovascular accidents.
At 3 to 4 months, the mean systolic blood pressure of patients with diabetes was 137.0 mmHg (SD=17.4) with candesartan compared with 137.4 mmHg (SD=12.5) at baseline, (p=0.91). The mean diastolic blood pressure changed from 77.0 mmHg (SD=4.9) at baseline to 73.5 mmHg (SD=6.7), (p=0.034).
At 3 to 4 months, the mean systolic blood pressure of patients with cardiovascular disease was 133.7 mmHg (SD=15.2) with candesartan compared with 134.1 mmHg (SD=13.7) at baseline, (p=0.87). The mean diastolic blood pressure changed from 75.6 mmHg (SD=6.4) at baseline to 70.6 mmHg (SD=8.9), (p=0.009).
At 3 to 4 months, the mean systolic blood pressure of patients without diabetes or cardiovascular disease was 137.2 mmHg (SD=13.5) with candesartan compared with 141.9 mmHg (SD=12.9) at baseline, (p=0.012). The mean diastolic blood pressure changed from 80.8 mmHg (SD=7.4) at baseline to 79.5 mmHg (SD=7.3), (p=0.19).
At 10 months one patient had two cerebrovascular accidents. The authors stated that it was unlikely that these events were due to the change in medication.