Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pipeline embolization device (Covidien ev3) for treatment of intracranial aneurysms. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2012 Authors' conclusions An intracranial aneurysm is a weakened area in the wall of an artery caused by changes in the vessel wall that cause bulging, which can lead to rupture and hemorrhage. An aneurysm can involve all of the vessel walls (a fusiform aneurysm), just one wall (saccular), or it can separate the vessel walls (dissecting). Nonsaccular intracranial aneurysms such as fusiform and dissecting aneurysms are rare with an incidence of less than 0.1%. Rupture of an intracranial aneurysm beneath the arachnoid membrane leads to bleeding into the brain or subarachnoid hemorrhage (SAH). More than 5% of stroke deaths are due to aneurysmal hemorrhage, and more than 50% of these patients die within the first 30 days after the event. Survivors are often left with permanent neurological deficits. The incidence of unruptured intracranial aneurysms in the U.S. adult population is approximately 6%. The treatment of intracranial aneurysms may be surgical, most often excluding the aneurysm from the parent artery by clipping, or by endovascular therapy with detachable coil embolization with or without the use of a supporting self-expanding microstent and/or the use of remodeling balloon angioplasty. While ruptured aneurysms are generally treated to reduce the risk of secondary rupture, the treatment of an unruptured aneurysm depends on its size, type, and location in the brain, as well as on the patient's general health and the presence of any comorbidities. The established endovascular technologies are frequently challenged by an unfavorable anatomical configuration and neck geometry of the aneurysm, and unique forms of recurrence and complications have been reported. These shortcomings have led to the development of a newer generation of endovascular implants. Indexing Status Subject indexing assigned by CRD MeSH Embolization, Therapeutics; Intracranial Aneurysm Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32013000266 Date abstract record published 17/04/2013 |